韩瑞敏

中国人民大学化学系，副教授

理工楼，521

电话：010-62516604

E-mail：rmhan@ruc.edu.cn

1．教育经历

2．研究工作经历

3．讲授课程

（1）《食品化学与安全》，本科生通识核心课程；

（2）《Chemistry for Food and Health》, 暑期国际学校本科生课程

（3）《结构化学》，本科生课程；

（4）《食品化学》，硕士研究生课程。

4．研究方向

（1）脂和蛋白的氧化-抗氧化反应机理;

（2）天然抗氧化剂及金属配合物的抗氧化自由基反应机理和动态结构;

（3）牛奶和红酒中的氧化-抗氧化反应机理。

5．主要科研项目

（1）国家自然科学基金面上项目：“钙离子介导类黄酮对聚集态蛋白质和脂质的抗氧化机制研究（22073114），2021/01–2024/12，主持、在研；

（2）国家自然科学基金面上项目：“类黄酮金属配合物的合成和抗氧化分子机理研究”（21573284），2016/01–2019/12，主持，已结题；

（3） 国家自然科学基金青年基金：“脂质体中类黄酮化合物的抗氧化自由基反应动力学研究”（20803091），2009/01–2011/12，主持，已结题。

6．已发表主要研究结果

(1) Liu, C.; Wang, W.-Z.; Song, M.-T.; Lu, Y.; Qian, L.-L.; Han, R.-M.*; Skibsted, L. H.; Zhang, J.-P. Radical Scavenging Efficiency of Flavonoids Increased by Calcium(II) Binding: Structure-Activity Relationship. ChemistrySelect, 2021, 6, 1.

(2) Lu, Y., Xu, Y., Song, M.-T., Qian, L.-L., Liu, X.-L., Gao, R.-Y., Han, R.-M.*, J.-P. Zhang, Skibsted, L. H., Promotion effects of flavonoids on browning induced by enzymatic oxidation of tyrosinase: structure-activity relationship. RSC Adv., 2021, 11, 13769.

(3) Xu, Y., Yang, J., Lu, Y., Qian, L.-L., Yang, Z.-Y., Han, R.-M.*, Zhang J.-P., Skibsted L.H.*, Copper(II) coordination and translocation in luteolin and effect on radical scavenging. J. Phys. Chem. B, 2020, 124, 380−388.

(4) Yang, Z.-Y., Qian, L.-L., Xu, Y., Song, M.-T., Liu, C., Han, R.-M.*, Zhang J.-P., Skibsted L.H. Kinetic studies on radical scavenging activity of kaempferol decreased by Sn(II) binding. Molecules. 2020, 25, 1975.

(5) Qian, L.-L., Lu, Y., Xu, Y., Yang, Z.-Y., Yang, J., Zhou, Y.-M., Han, R.-M.*, Zhang, J.-P., Skibsted, L.H. Alkaline earth metal ion coordination increases radical scavenging efficiency of kaempferol. RSC Adv., 2020, 10, 30035.

(6) Y. Xu, J. Yang, Y. Lu, Z.-Y. Yang, R.-M. Han*, J.-P. Zhang, L. H. Skibsted, Kaempferol binding to zinc(II), efficient radical scavenging through increased phenol acidity J. Phys. Chem. B., 2018, 122, 10108.

(7) J. Yang, Y. Xu, H.-Y. Liu, R.-M. Han*, J.-P. Zhang, L. H. Skibsted*, Genistein binding to copper(II). Solvent dependence and effects on radical scavenging. Molecules. 2017, 22, 1757.

(8) J. C. M. Pereira, A. V. Iretskii, R.-M. Han*, P. C. Ford*, Dinitrosyl iron complexes with cysteine. Kinetics studies of the formation and reactions of DNICs in aqueous solution. J. Am. Chem. Soc., 2015, 137, 328.

(9) R.-M. Han, H. Cheng, R. Feng, D.-D. Li, W. Lai*, J.-P. Zhang, L. H. Skibsted*, β‑Carotene as a lipophilic scavenger of nitric oxide. J. Phys. Chem. B, 2014, 118, 11659.

(10) D.-D. Li, R.-M. Han,* R. Liang, C.-H. Chen, W. Lai, J.-P. Zhang, L. H. Skibsted*, Hydroxyl Radical Reaction with trans-Resveratrol: Initial Carbon Radical Adduct Formation Followed by Rearrangement to Phenoxyl Radical. J. Phys. Chem. B, 2012, 116, 7154.

(11) R.-M. Han*, J.-P. Zhang*, L. H. Skibsted, Reaction Dynamics of Flavonoids and Carotenoids as Antioxidants. Molecules, 2012, 17, 2140.

(12) R.-M. Han*, D.-D. Li, C.-H. Chen, R. Liang, Y.-X. Tian, J.-P. Zhang, L. H. Skibsted*, Phenol acidity and ease of oxidation in isoflavonoid/β-carotene antioxidant synergism. J. Agric. Food Chem. 2011, 59, 10367.

(13) C.-H. Chen, R.-M. Han*, R. Liang, L.-M. Fu, P. Wang, X.-C. Ai, J.-P. Zhang, L. H. Skibsted. Direct observation of β-carotene reaction with hydroxyl radical. J. Phys. Chem. B, 2011, 115, 2082.