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杜为红 副教授

专业:物理化学

电话:010-62512660传真:010-62516444

电子邮件:whdu@chem.ruc.edu.cn

教育背景

1986.9-1990.7, 山西大学化学系, 本科

1990.9-1993.7, 山西大学分子科学研究所, 硕士

1997.9-2000.7, 北京大学化学与分子工程学院, 博士

工作经历

1993.7-1997.8, 山西大学化学系,教师

2000.9-2001.3, 香港大学化学系,博士后

2001.4-2003.4, 美国加州大学戴维斯分校化学系,博士后

2003.8-2005.5, 北京师范大学化学系, 教师

2005.6-, 中国人民大学化学系,教师

教授课程

物理化学(本科);生物物理化学(研究生)

主要研究方向:生物物理与生物无机化学

主要研究内容

  1. 生物大分子与配体相互作用的光谱学、波谱学研究

2. 生物毒素的结构与功能关系

3. 生物大分子与小分子相互作用的热动力学

主要科研项目与课题

中国人民大学引进人才资助项目 50万元

国家自然科学基金面上项目 26万元

教育部科学技术重点项目 10万元

973 计划子课题 20万元

主要发表论文:

1. Jia Xu, Gowei Yin, Weihong Du*. Distal mutation modulates the heme sliding in mouse neuroglobin investigated by molecular dynamics simulation. Proteins. Struc. Func. Bioinfo. 2011, 79, 191-202.

2. Yanli Wang, Jia Xu, Lu Wang, Bingbing Zhang, Weihong Du*. Interaction of the human prion protein PrP106-126 with metal complexes: potential therapeutic agents against prion disease. Chemistry, Eur. J. 2010, 16, 13339-42.

3. Yanli Wang, Tong Zhang*, Jia Xu, Weihong Du*. Comparison of the binding affinity of chlorogenic acid with two serum albumins. Int. J. Biol. Macromol. 2010, in press.

4. Jia Xu, Yanli Wang, Binbin Zhang, Baohuai Wang, Weihong Du*. Stereochemistry of 4-hydroxyproline affects the conformation of conopeptides. Chem. Commun. 2010, 46, 5467-5469.

5. Jia Xu, Guowei Yin, Feijuan Huang, Baohuai Wang, Weihong Du*. Molecular dynamics simulation of a carboxy murine neuroglobin mutated on the proximal side: heme displacement and concomitant rearrangement in loop regions J. Mol. Model. 2010, 16, 759-770.

6. Bin Gao, Jia Xu, Maria del Carmen Rodrigues, Humberto Lanz-Mendoza, Rosaura Hernondez -Rivas, Weihong Du*, Shunyi Zhu*. Characterization of two linear cationic antimalarial peptides in the scorpion mesobuthus eupeus. Biochimie 2010, 92, 350-359.

7. Jia Xu, Lianzhi Li, Guowei Yin, Haili Li, Weihong Du*. Ligand orientation of human neuroglobin obtained from solution NMR and molecular dynamics simulation as compared with X-ray crystallography. J. Inorg. Biochem. 2009, 103, 1693-1701.

8. Feijuan Huang, Weihong Du*, Solution Structure of Hyp10Pro variant of conomarphin, a cysteine-free and D-amino-acid containing conopeptide. Toxicon, 2009, 54, 153-160.

9. Yuhong Han, Feijuan Huang, Hui Jiang, Li Liu, Qi Wang, Yanfang Wang, Xiaoxia Shao, Chengwu Chi, Weihong Du* and Chunguang Wang* , Purification and structural characterization of a D-amino acid containing conopeptide, conomarphin, from conus marmoreus. FEBS J. 2008, 275, 1976-1987.

10. Guowei Yin, Yanjie Li, Juan Li, Jing Li, Weihong Du*, Qun Wei*, Weihai Fang. Solution H-1 NMR study of the active site structure for the double mutant H64Q/V68F cyanide complex from mouse neuroglobin. Biophys. Chem. 2008, 136, 115-123.

11. Weihong Du, Yuhong Han, Feijuan Huang, Juan Li, Chengwu Chi, Weihai Fang*. Solution structure of an M-1 Conotoxin mr3e with a novel disulfide linkage. FEBS J. 2007, 274, 2596-2602.

12. Yiming Li, Guowei Yin, Wei Wei, Hengbin Wang, Shanhao Jiang, Duyuan Zhu*, Weihong Du*, Interactions of Lycopodium alkaloids with acetylcholinesterase investigated by 1H NMR relaxation rate, Biophys. Chem. 2007, 129, 212-217.

13. Weihong Du, Ling Wang, Baohuai Wang, Zhifen Li, Weihai Fang*. Actinoimycin D binds to single stranded DNA oligomers  which contains double GTC triplets. Thermochimica Acta 2007, 452, 31-35.

14. Weihong Du, Ray Syvitski, Sylvia Dewilde, Luc Moens, and Gerd N. La Mar*. Solution 1H NMR Characterization of Equilibrium Heme Orientational Disorder with Functional Consequence in Mouse Neuroglobin. J. Am. Chem. Soc. 2003, 125, 8080-8081.

15. Weihong Du, Zhicheng Xia, Sylvia Dewilde, Luc Moens, Gerd N. La Mar*. 1H NMR  study of the molecular structure and magnetic properties of the active site for the cyanomet complex of O2-avid globin from trametode Paraphistomum epiclitum. Eur. J. Biochem. 2003, 270, 2707-2720.

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